Cancer BiologybioRxivPreprint
The tyrosine kinase inhibitor GNF-7 targets senescent cells through allosteric activation of GCN2.
Gema López-Pernas, Matilde Murga, Wareed Ahmed…·Óscar Fernández-Capetillo
This study identifies GNF-7 as a senolytic drug that activates GCN2 to kill senescent cells, showing synergy with CDK4/6 inhibitors in preclinical models.