Author

Alicia G. Serrano

Spanish National Cancer Research Centre

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:clinical cohort / trial· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

Gema López-PernasiD· 2 shared Joaquı́n PastoriD· 2 shared Marta Elena Antón· 2 shared Matilde MurgaiD· 2 shared Óscar Fernández-CapetilloiD· 2 shared Belén Navarro‐GonzáleziD· 1 shared Brinton A. Seashore-LudlowiD· 1 shared Carlota Cardona· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Gema López-PernasORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

The tyrosine kinase inhibitor GNF-7 targets senescent cells through allosteric activation of GCN2.

Gema López-Pernas, Matilde Murga, Wareed Ahmed, Maria Häggblad, Elena Jiménez‐Ortega, Alicia G. Serrano, Carlota Cardona, Mario Lopez-Prieto, Samuele Fisicaro, Jorge Mota‐Pino, Belén Navarro‐González, Eduardo Zarzuela, Marta Elena Antón, Louise Lidemalm, Sonia Martinez, , Óscar Fernández-Capetillo

This study identifies GNF-7 as a senolytic drug that activates GCN2 to kill senescent cells, showing synergy with CDK4/6 inhibitors in preclinical models.

bioRxiv · Aug 29, 2025 · PreprintCancer Biology

SETD8 inhibition targets cancer cells with increased rates of ribosome biogenesis

Matilde Murga, Gema López-Pernas, Robert Soliva, Elena Fueyo‐Marcos, Corina Amor, Ignacio Faustino, Marina Serna, Alicia G. Serrano, Lucía Díaz, Sonia Martı́nez, Carmen Blanco‐Aparicio, Marta Elena Antón, Brinton A. Seashore-Ludlow, Joaquı́n Pastor, Rozbeh Jafari, , Óscar Fernández-Capetillo

This study identifies novel SETD8 inhibitors and shows their toxicity correlates with ribosome biogenesis regulators, suggesting a biomarker for targeted cancer therapy.

Cell Death and Disease · Sep 28, 2024Peer-reviewedCancer Biology