Matilde Murga

The paper identifies RUVBL1/2-RPAP3 interface as a vulnerability and develops de novo protein binders that selectively disrupt R2TP, reducing PIKK levels without affecting other RUVBL1/2 complexes.

The paper identifies genetic factors that influence cancer cells' sensitivity to nucleolar stress-inducing drugs through CRISPR screens, revealing roles for P53, RB1, and PI3K/mTOR signaling.

This study identifies GNF-7 as a senolytic drug that activates GCN2 to kill senescent cells, showing synergy with CDK4/6 inhibitors in preclinical models.

This study identifies novel SETD8 inhibitors and shows their toxicity correlates with ribosome biogenesis regulators, suggesting a biomarker for targeted cancer therapy.