Gema López-Pernas

Disruption of R2TP-mediated PIKK maturation with de novo designed binders

The paper identifies RUVBL1/2-RPAP3 interface as a vulnerability and develops de novo protein binders that selectively disrupt R2TP, reducing PIKK levels without affecting other RUVBL1/2 complexes.

The tyrosine kinase inhibitor GNF-7 targets senescent cells through allosteric activation of GCN2.

This study identifies GNF-7 as a senolytic drug that activates GCN2 to kill senescent cells, showing synergy with CDK4/6 inhibitors in preclinical models.

SETD8 inhibition targets cancer cells with increased rates of ribosome biogenesis

This study identifies novel SETD8 inhibitors and shows their toxicity correlates with ribosome biogenesis regulators, suggesting a biomarker for targeted cancer therapy.