PhysiologybioRxivPreprint
The fetal hydrops-associated single-residue mutation L322P abolishes mechanical but not chemical activation of the PIEZO1 ion channel
Jinghui Jiang, Wei Guo, Xudong Chen…·Bailong Xiao
The paper identifies a mutation in PIEZO1 that abolishes mechanical activation but not chemical activation, showing a direct link between mechanosensitivity and fetal hydrops.