Jan Stanislaw Nowak

The paper introduces CheMelt, a tool for analyzing thermal and chemical denaturation of proteins, and shows de novo designed proteins have lower thermodynamic parameters than natural proteins.

This study uses isothermal titration calorimetry to analyze the thermodynamics of CO2 capture by amino acids and peptides, revealing distinct optimization strategies for carbamate formation.

This study uses FIDA to screen computationally designed protein binders in unpurified lysates, identifying high-affinity binders efficiently.

This study shows that the Bri2 BRICHOS domain inhibits α-synuclein oligomer formation and toxicity by suppressing secondary nucleation and binding oligomers, suggesting its potential as a therapeutic target for Parkinson's disease.