Author

Carla A. Espinoza

University of California, San FranciscoORCID 0009-0000-8702-0319Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Natalia JuraiD· 3 shared Edmond M. LinossiiD· 2 shared Gabriella O. EstevamiD· 2 shared James S. FraseriD· 2 shared Albert XuiD· 1 shared Angela L. Gao· 1 shared Christian B. MacdonaldiD· 1 shared Eric Andrew CollissoniD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiochemistry

Natalia JuraORCID

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3 papers

Recent·Most cited

BiochemistryBiochemical JournalPeer-reviewedDec 1, 2025

Autoregulation of the MET Receptor Tyrosine Kinase by its Intracellular Juxtamembrane Domain

Edmond M. Linossi, Carla A. Espinoza, Gabriella O. Estevam…·Natalia Jura

This study identifies a role for the MET juxtamembrane domain in accelerating kinase activation through an allosteric mechanism, with implications for MET-driven cancer therapies.

1 citation

humanproteomics

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Cell BiologyMolecular Biology of the CellPeer-reviewedOct 2, 2024

Protein-protein interactions with G3BPs drive stress granule condensation and gene expression changes under cellular stress

José M. Liboy-Lugo, Carla A. Espinoza, Jessica Sheu‐Gruttadauria…·Stephen N. Floor

The paper identifies key residues in G3BPs that drive stress granule formation and gene expression changes under cellular stress, with G3BP2B showing specific roles in ER stress.

10 citations

humanbulk RNA-seq

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Molecular BiologyeLifePeer-reviewedOct 2, 2023

Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain.

Gabriella O. Estevam, Edmond M. Linossi, Christian B. Macdonald…·James S. Fraser

15 citations

humanproteomics

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