Author

Edmond M. Linossi

University of California, San FranciscoORCID 0000-0002-8039-573XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:proteomics· 4 Approach:experimental assay· 3 Approach:biophysical modeling· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Gabriella O. EstevamiD· 3 shared James S. FraseriD· 3 shared Natalia JuraiD· 3 shared Carla A. EspinozaiD· 2 shared Christian B. MacdonaldiD· 2 shared Eric Andrew CollissoniD· 2 shared Willow Coyote‐MaestasiD· 2 shared Alexandra L. GarnhamiD· 1 shared

Activity by Year

2023-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersBiochemistry

Gabriella O. EstevamORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ARAP2 regulates responses to interferon-gamma by restricting SOCS1

Narelle Keating, Karen Doggett, Grace M. Bidgood, Lizeth G. Meza Guzman, Laura F. Dagley, Kunlun Li, Bailey E. Williams, Anna Gabrielyan, Carolina Alvarado, Benjamin J. Broomfield, Brigette C. Duckworth, Colin Hockings, Jumana M. Yousef, Evelyn Leong, Rhiannon Morris, , Sandra E. Nicholson

This study identifies ARAP2 as a regulator of IFN-gamma signaling by modulating SOCS1 function through a phosphorylation-dependent interaction.

Cell Reports · Dec 1, 2025Peer-reviewedCell Biology

Autoregulation of the MET Receptor Tyrosine Kinase by its Intracellular Juxtamembrane Domain

Edmond M. Linossi, Carla A. Espinoza, Gabriella O. Estevam, James S. Fraser, Natalia Jura

This study identifies a role for the MET juxtamembrane domain in accelerating kinase activation through an allosteric mechanism, with implications for MET-driven cancer therapies.

Biochemical Journal · Dec 1, 2025Peer-reviewedBiochemistry

Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning

Gabriella O. Estevam, Edmond M. Linossi, Jingyou Rao, Christian B. Macdonald, Ashraya Ravikumar, Karson M Chrispens, John A. Capra, Willow Coyote‐Maestas, Harold Pimentel, Eric Andrew Collisson, Natalia Jura, James S. Fraser

The paper uses deep mutational scanning to analyze MET kinase domain mutations and their resistance to 11 inhibitors, identifying resistance and sensitizing mutations and improving prediction with a protein language model.

eLife · Feb 17, 2025Peer-reviewedCancer Biology

Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain.

Gabriella O. Estevam, Edmond M. Linossi, Christian B. Macdonald, Carla A. Espinoza, Jennifer M. Michaud, Willow Coyote‐Maestas, Eric Andrew Collisson, Natalia Jura, James S. Fraser

eLife · Oct 2, 2023Peer-reviewedMolecular Biology