Cancer BiologybioRxivPreprint
EGFR suppression and drug-induced potentiation are widespread features of oncogenic RTK fusions
Yuzhi Gao, David Gonzalez-Martinez, Sofia Wissert…·Lukasz J. Bugaj
The paper shows that RTK fusions suppress EGFR and sequester Grb2, and targeted therapies reverse this suppression, enhancing EGFR signaling and drug response.
3 citations