Author

Sofia Wissert

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

David Gonzalez-MartineziD· 2 shared Lukasz J. BugajiD· 2 shared Anh Le· 1 shared Delaney WildeiD· 1 shared Elizabeth Rhoades· 1 shared Emily Brackhahn· 1 shared Hana BaderiD· 1 shared Nidhi SahniiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

David Gonzalez-MartinezORCID

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2 papers

Recent·Most cited

Low-order assemblies drive oncogenic RTK fusion signaling without condensation

David Gonzalez-Martinez, Thomas R. Mumford, Delaney Wilde, Sofia Wissert, Yuzhi (Carol) Gao, Emily Brackhahn, Richard Kriwacki, Elizabeth Rhoades, Lukasz J. Bugaj

This study shows that low-order RTK fusions can drive oncogenic signaling without forming condensates, challenging the role of condensation in signal transmission.

bioRxiv · Dec 13, 2025 · PreprintCancer Biology

EGFR suppression and drug-induced potentiation are widespread features of oncogenic RTK fusions

Yuzhi Gao, David Gonzalez-Martinez, Sofia Wissert, Hana Bader, Nidhi Sahni, Anh Le, Robert Charles Doebele, Lukasz J. Bugaj

The paper shows that RTK fusions suppress EGFR and sequester Grb2, and targeted therapies reverse this suppression, enhancing EGFR signaling and drug response.

bioRxiv · Nov 19, 2025 · PreprintCancer Biology