Author

David Gonzalez-Martinez

University of PennsylvaniaORCID 0000-0003-1782-9133Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Organism:E. coli· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Lukasz J. BugajiD· 3 shared Sofia Wissert· 2 shared Anh Le· 1 shared Brian Y. ChowiD· 1 shared Delaney WildeiD· 1 shared Elizabeth Rhoades· 1 shared Emily Brackhahn· 1 shared Gabrielle H. HoiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCancer Biology

Lukasz J. BugajORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintDec 13, 2025

Low-order assemblies drive oncogenic RTK fusion signaling without condensation

David Gonzalez-Martinez, Thomas R. Mumford, Delaney Wilde…·Lukasz J. Bugaj

This study shows that low-order RTK fusions can drive oncogenic signaling without forming condensates, challenging the role of condensation in signal transmission.

1 citation

humanproteomics

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Cancer BiologybioRxivPreprintNov 19, 2025

EGFR suppression and drug-induced potentiation are widespread features of oncogenic RTK fusions

Yuzhi Gao, David Gonzalez-Martinez, Sofia Wissert…·Lukasz J. Bugaj

The paper shows that RTK fusions suppress EGFR and sequester Grb2, and targeted therapies reverse this suppression, enhancing EGFR signaling and drug response.

3 citations

humanproteomics

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Synthetic BiologyCommunications BiologyPeer-reviewedNov 24, 2023

High-throughput feedback-enabled optogenetic stimulation and spectroscopy in microwell plates

William K. J. Benman, Saachi Datta, David Gonzalez-Martinez…·Lukasz J. Bugaj

The paper introduces an open-source device for high-throughput optogenetic experiments in microwell plates, enabling automated stimulation, spectroscopy, and feedback control in E. coli.

11 citations

E. coliimaging

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