Leo J. Gorham

This study identifies β-lactam targets in Mycobacterium abscessus using chemoproteomics, revealing 17 conserved targets and demonstrating imipenem's superior inhibition over cefoxitin.

The paper uses activity-targeted metaproteomics to study rare syntrophic bacteria in anaerobic communities, revealing their metabolic activity and a previously hypothesized oxidative glycine pathway.

This study identifies 30 Mtb enzymes inhibited by meropenem, revealing polypharmacology beyond known cell wall targets.

This study identifies non-opioid receptor proteins that interact with fentanyl across multiple species and tissues using photoaffinity probes and molecular docking.