Damon T. Leach

The paper analyzes multi-omic, multi-tissue molecular responses to acute exercise in sedentary adults, identifying key pathways and exerkines involved in exercise effects.

The paper identifies shared and distinct biochemical responses to different exercise modes through plasma proteomics, metabolomics, and transcriptomics in sedentary humans.

This study identifies shared and sex-specific molecular responses to endurance training in skeletal muscle using multi-omics data from rats.

ChatGEM enables interactive simulation of genome-scale metabolic models via natural language, improving performance and reducing execution time for complex tasks.

This study identifies β-lactam targets in Mycobacterium abscessus using chemoproteomics, revealing 17 conserved targets and demonstrating imipenem's superior inhibition over cefoxitin.

The paper develops and refines methods to sample and sequence cyanobacteria, cyanophages, and their environment in the Salish Sea to study host-pathogen dynamics.

This study identifies 30 Mtb enzymes inhibited by meropenem, revealing polypharmacology beyond known cell wall targets.

This study characterizes the proteomic changes in Mycobacterium tuberculosis under carbon starvation, revealing extensive reprogramming and retention of cell wall biosynthesis enzymes.

This study characterizes the chemodiversity of root exudates in tall wheatgrass, revealing a diverse lipid composition and higher carbon content in hydrophobic exudates.

This study identifies non-opioid receptor proteins that interact with fentanyl across multiple species and tissues using photoaffinity probes and molecular docking.