Vivian Lin

Carbon starvation of Mycobacterium abscessus induces a non-replicating state with extensive proteomic remodeling

This study identifies extensive proteomic changes in Mycobacterium abscessus under carbon starvation, highlighting the role of the DosRS system in non-replicating persistence.

Reference-free compound identification using computational prediction of molecular properties and multi-dimensional spectrometric measurements: a fentanyl case study

This paper identifies unknown molecules without reference libraries by combining computational predictions with spectrometric data, achieving exact identifications in a fentanyl case study.

Chemoproteomic elucidation of β-lactam drug targets in Mycobacterium abscessus

This study identifies β-lactam targets in Mycobacterium abscessus using chemoproteomics, revealing 17 conserved targets and demonstrating imipenem's superior inhibition over cefoxitin.

Activity-targeted metaproteomics uncovers rare syntrophic bacteria central to anaerobic community metabolism

The paper uses activity-targeted metaproteomics to study rare syntrophic bacteria in anaerobic communities, revealing their metabolic activity and a previously hypothesized oxidative glycine pathway.

Comprehensive identification of β-lactam antibiotic polypharmacology in Mycobacterium tuberculosis

This study identifies 30 Mtb enzymes inhibited by meropenem, revealing polypharmacology beyond known cell wall targets.

Proteomic characterization of Mycobacterium tuberculosis subjected to carbon starvation

This study characterizes the proteomic changes in Mycobacterium tuberculosis under carbon starvation, revealing extensive reprogramming and retention of cell wall biosynthesis enzymes.

Discovery of non-opioid receptor protein targets of fentanyl across tissues from animal models and humans using photoaffinity probes

This study identifies non-opioid receptor proteins that interact with fentanyl across multiple species and tissues using photoaffinity probes and molecular docking.