Aaron Wright

Perturbation-based propagation of bacterial composition uncertainty improves robustness and reproducibility of microbiome differential abundance analysis.

PARALLAX improves microbiome differential abundance analysis by addressing compositional data, uncertainty, and experimental design through a unified framework with stability-based metrics.

Chronic stress remodels gut bacterial ecology and polysaccharide metabolism with neuroendocrine consequences despite unchanged behavior

This study shows chronic stress alters gut bacterial function and metabolism, affecting neuroendocrine pathways without changing behavior in mice.

Commensal Bacteria in the Gut Microbiome Encode Previously Unrecognized Aromatic Hydrocarbon Catabolic Machinery

This study identifies aromatic hydrocarbon catabolic machinery in gut commensals using murine models, metaproteomics, and chemoproteomics, revealing functional differences between intestinal compartments.

Comprehensive identification of β-lactam antibiotic polypharmacology in Mycobacterium tuberculosis

This study identifies 30 Mtb enzymes inhibited by meropenem, revealing polypharmacology beyond known cell wall targets.

Discovery of non-opioid receptor protein targets of fentanyl across tissues from animal models and humans using photoaffinity probes

This study identifies non-opioid receptor proteins that interact with fentanyl across multiple species and tissues using photoaffinity probes and molecular docking.

Discovery of active mouse, plant and fungal cytochrome P450s in endogenous proteomes and upon expression in planta.

The paper identifies active cytochrome P450s in mouse, plant, and fungal systems using chemical probes and mass spectrometry, showing their subcellular localization and activity-based labeling.