Kimberly E. Beatty

Carbon starvation of Mycobacterium abscessus induces a non-replicating state with extensive proteomic remodeling

This study identifies extensive proteomic changes in Mycobacterium abscessus under carbon starvation, highlighting the role of the DosRS system in non-replicating persistence.

Chemoproteomic elucidation of β-lactam drug targets in Mycobacterium abscessus

This study identifies β-lactam targets in Mycobacterium abscessus using chemoproteomics, revealing 17 conserved targets and demonstrating imipenem's superior inhibition over cefoxitin.

Comprehensive identification of β-lactam antibiotic polypharmacology in Mycobacterium tuberculosis

This study identifies 30 Mtb enzymes inhibited by meropenem, revealing polypharmacology beyond known cell wall targets.

Combinations comprising dual β-lactams and a β-lactamase inhibitor achieve optimal synergistic inhibition of Mycobacterium abscessus growth

This study shows that combinations of dual β-lactams and β-lactamase inhibitors synergistically inhibit Mycobacterium abscessus growth, challenging the traditional view of their mechanisms.

Proteomic characterization of Mycobacterium tuberculosis subjected to carbon starvation

This study characterizes the proteomic changes in Mycobacterium tuberculosis under carbon starvation, revealing extensive reprogramming and retention of cell wall biosynthesis enzymes.