Oscar C. Bedoya-Reina

This study identifies circadian gene network disruption in high-risk neuroblastoma across multiple biological contexts, showing it is a network-level alteration rather than a single-gene effect.

The paper identifies chromaffin-neuroblast plasticity as a mechanism linking paraganglioma and neuroblastoma through shared developmental states and hybrid cell populations.

This study shows ALK R1275Q mutation sustains an immature SCP-like cell state during sympathoadrenal commitment, increasing susceptibility to MYCN-driven neuroblastoma initiation.

This study repurposes statins and phenothiazines to treat chemoresistant neuroblastoma, showing synergistic effects and improved survival in preclinical models.

This paper shows that HIF2α reduces MYCN protein levels and promotes a low-risk noradrenergic phenotype in neuroblastoma, suggesting HIF2 has tumor suppressor rather than oncogenic function.

This study shows that γδT cells can selectively kill medulloblastoma cells without harming neurons or stem cells, offering a safer and more effective treatment option.

The paper develops genomic resources and workflows for two threatened Acropora corals, identifies genetic differences in key pathways, and provides candidate loci for genotyping.

This study identifies genetic changes in woolly mammoths that underlie adaptations to arctic environments by analyzing genome sequences and functionally testing specific genes.