Morgan Holcomb

Intranasal CRISPR- lipid nanoparticles targeting MAPK9 reduce neuroinflammation after traumatic brain injury

This paper develops an intranasal CRISPR-based therapy targeting MAPK9 in microglia to reduce neuroinflammation after traumatic brain injury, showing reduced inflammation and no toxicity.

Simulated spaceflight disrupts the immune-gut-brain axis and drives sex-dependent neuroinflammation, axonal injury, and behavioral deficits.

This study shows that simulated spaceflight stressors disrupt the immune-gut-brain axis, causing sex-dependent neuroinflammation, axonal injury, and behavioral issues in mice.

Telomerase mRNA-Lipid nanoparticles attenuate neuroinflammation after traumatic brain injury in mice

This paper shows that delivering telomerase mRNA via lipid nanoparticles reduces neuroinflammation and oxidative stress after traumatic brain injury in mice.

Sex-specific effects of fecal microbiota transplantation on TBI-exacerbated Alzheimer's pathology in mice

This study investigates how fecal microbiota transplantation (FMT) affects Alzheimer's pathology and neuroinflammation in male and female mice with traumatic brain injury, finding sex-specific outcomes.

Antibiotic-induced changes to the gut microbiome attenuate neuroinflammation in a mouse model of TBI

This study shows that antibiotic treatment reduces neuroinflammation and neurodegeneration after TBI in mice by altering the gut microbiome.

Probiotic treatment causes sex-specific neuroprotection after traumatic brain injury in mice

This study shows that probiotic treatment reduces TBI severity and behavioral deficits in male mice but not female mice.

Sex-dependent improvement in traumatic brain injury outcomes after liposomal delivery of dexamethasone in mice.

This study shows that liposomal dexamethasone reduces TBI lesion volume and inflammation in male mice but not females.