Sonia Villapol

Female-Biased IL-17/STAT3 Signaling Marks Dementia-Associated Microglial Inflammation in Alzheimer's Disease

The paper identifies a female-biased IL-17/STAT3 signaling program in microglia associated with dementia in Alzheimer's disease using single-cell transcriptomics.

Intranasal CRISPR- lipid nanoparticles targeting MAPK9 reduce neuroinflammation after traumatic brain injury

This paper develops an intranasal CRISPR-based therapy targeting MAPK9 in microglia to reduce neuroinflammation after traumatic brain injury, showing reduced inflammation and no toxicity.

Simulated spaceflight disrupts the immune-gut-brain axis and drives sex-dependent neuroinflammation, axonal injury, and behavioral deficits.

This study shows that simulated spaceflight stressors disrupt the immune-gut-brain axis, causing sex-dependent neuroinflammation, axonal injury, and behavioral issues in mice.

Telomerase mRNA-Lipid nanoparticles attenuate neuroinflammation after traumatic brain injury in mice

This paper shows that delivering telomerase mRNA via lipid nanoparticles reduces neuroinflammation and oxidative stress after traumatic brain injury in mice.

Sex-specific effects of fecal microbiota transplantation on TBI-exacerbated Alzheimer's pathology in mice

This study investigates how fecal microbiota transplantation (FMT) affects Alzheimer's pathology and neuroinflammation in male and female mice with traumatic brain injury, finding sex-specific outcomes.

Antibiotic-induced changes to the gut microbiome attenuate neuroinflammation in a mouse model of TBI

This study shows that antibiotic treatment reduces neuroinflammation and neurodegeneration after TBI in mice by altering the gut microbiome.

Probiotic treatment causes sex-specific neuroprotection after traumatic brain injury in mice

This study shows that probiotic treatment reduces TBI severity and behavioral deficits in male mice but not female mice.

Sex-dependent improvement in traumatic brain injury outcomes after liposomal delivery of dexamethasone in mice.

This study shows that liposomal dexamethasone reduces TBI lesion volume and inflammation in male mice but not females.

Fecal microbiota transplantation derived from Alzheimer's disease mice worsens brain trauma outcomes in wild-type controls

This study shows that fecal microbiota from Alzheimer's mice worsens brain injury outcomes in healthy mice.

Emu: Species-Level Microbial Community Profiling for Full-Length Nanopore 16S Reads

Emu provides species-level microbial community profiling using full-length 16S rRNA reads with improved accuracy over existing methods.

Hidden genomic diversity of SARS-CoV-2: implications for qRT-PCR diagnostics and transmission

This study analyzes over 7,000 SARS-CoV-2 datasets to reveal genomic diversity, showing iSNVs and small indels drive variation, and highlights implications for qRT-PCR and transmission tracking.