Fernando Gómez‐Pinilla

Probiotic treatment causes sex-specific neuroprotection after traumatic brain injury in mice

This study shows that probiotic treatment reduces TBI severity and behavioral deficits in male mice but not female mice.

Thyroid Hormone T4 Mitigates Traumatic Brain Injury by Dynamically Remodeling Cell Type Specific Genes, Pathways, and Networks in Hippocampus and Frontal Cortex

This study shows T4 treatment alters cell-type specific genes, pathways, and networks in hippocampus and frontal cortex after mTBI, reversing mTBI-affected genes and pathways.

JSTA: joint cell segmentation and cell type annotation for spatial transcriptomics

JSTA improves spatial transcriptomics accuracy by jointly segmenting cells and annotating their types, revealing detailed spatial gene expression patterns in mouse hippocampus.

Microvascular Injury in Mild Traumatic Brain Injury Accelerates Alzheimer-like Pathogenesis in Mice

This study shows that microvascular injury from mild TBI accelerates Alzheimer-like pathology in mice, suggesting vascular repair could mitigate AD risk.

Multi-tissue Multi-omics Nutrigenomics Indicates Context-specific Effects of DHA on Rat Brain

This study shows DHA has different effects on rat brain gene expression, pathways, and metabolic outcomes depending on dietary context.

Host Genetic Background and Gut Microbiota Contribute to Differential Metabolic Responses to High Fructose Consumption in Mice

This study shows that gut microbiota differences between mouse strains contribute to varied metabolic responses to high fructose consumption, with Akkermansia playing a key protective role.

Secondary single-cell transcriptomic analysis reveals common molecular signatures of cerebrovascular injury between traumatic brain injury and aging

The paper identifies common molecular signatures of cerebrovascular injury in traumatic brain injury and aging using single-cell RNA-seq data from mouse models.

Differential Metabolic and Multi-tissue Transcriptomic Responses to Fructose Consumption among Genetically Diverse Mice

This study examines how fructose affects metabolic and transcriptomic responses in genetically diverse mice, identifying strain-specific pathways and regulators involved in metabolic dysfunctions.

Single Cell Molecular Alterations Reveal Pathogenesis and Targets of Concussive Brain Injury

This study uses single-cell sequencing to identify hippocampal cell types and genes vulnerable to concussive TBI, revealing pathogenic mechanisms and therapeutic targets.