This study identifies the USP18-STAT2 axis as a critical factor enhancing hepatic resilience under proteotoxic stress by modulating interferon signaling and ISG solubility.

Cell Communication and Signaling · Oct 29, 2026Peer-reviewedCell Biology

Transient efferocytosis-induced activation of IKKβ reprograms macrophages to promote tissue resolution

David Ngai, Saheli Chowdhury, Santosh Reddy Sukka, George Kuriakose, Brian T Havens, Mustafa Yalçınkaya, Jeremy M. Frey, Heather Doviak, Jennifer W. Bradford, Bernhard Dorweiler, Hanna Winter, Lars Mäegdefessel, Kenneth Walsh, Joshua P. Thaler, Alan R. Tall, Ira A. Tabas

This study identifies IKKβ activation as a transient upstream signal triggered by efferocytosis that promotes tissue resolution through multiple downstream pathways.

Nature Communications · Oct 26, 2026Peer-reviewedImmunology

Deubiquitinase JOSD1 tempers hepatic proteotoxicity

Saheli Chowdhury, Abhishek Sen, Debajyoti Das, Partha Chakrabarti

This study identifies JOSD1 as a deubiquitinase that mitigates hepatic proteotoxicity by stabilizing SOCS1 and enhancing cell survival under proteasome inhibitor stress.

Cell Death Discovery · Sep 16, 2024Peer-reviewedCell Biology