Astrid Wachter

The paper examines transcriptomic changes in Alzheimer's disease brain regions associated with Aβ plaques, tangles, and APOE ε4, finding distinct gene expression patterns linked to neuroinflammation and neuronal dysfunction.

The paper analyzes endothelial cell heterogeneity across brain regions in Alzheimer's disease using single nucleus RNAseq, revealing region-specific gene expression changes and disease-related transcriptomic alterations.

This study uses single-nucleus RNA-sequencing to analyze astrocyte transcriptomic changes across the spatiotemporal progression of Alzheimer's disease, revealing gene expression trajectories and heterogeneity.

ABACUS improves sNuc-RNAseq analysis by incorporating intronic reads, doubling the number of identified nuclei in human brain data and enhancing cluster resolution.

The paper profiles microglia transcriptomes in AD donors and non-demented elderly using bulk and single-cell RNA sequencing, finding no significant differences in gene expression or subcluster composition.