Knut Biber

Exploring the Abeta Plaque Microenvironment in Alzheimer's Disease Mice by Multimodal Lipid-Protein-Histology Imaging on a Benchtop Mass Spectrometer

The paper develops a multimodal imaging workflow to analyze A{beta} plaque microenvironments in AD mice using mass spectrometry, histology, and immunohistochemistry on a benchtop instrument.

Distinct Transcriptomic Responses to A beta plaques, Neurofibrillary Tangles, and APOE in Alzheimer's Disease

The paper examines transcriptomic changes in Alzheimer's disease brain regions associated with Aβ plaques, tangles, and APOE ε4, finding distinct gene expression patterns linked to neuroinflammation and neuronal dysfunction.

Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer's disease

This study uses single-nucleus RNA-sequencing to analyze astrocyte transcriptomic changes across the spatiotemporal progression of Alzheimer's disease, revealing gene expression trajectories and heterogeneity.

ABACUS: A flexible UMI counter that leverages intronic reads for single-nucleus RNAseq analysis

ABACUS improves sNuc-RNAseq analysis by incorporating intronic reads, doubling the number of identified nuclei in human brain data and enhancing cluster resolution.

Profiling microglia from AD donors and non-demented elderly in acute human post-mortem cortical tissue

The paper profiles microglia transcriptomes in AD donors and non-demented elderly using bulk and single-cell RNA sequencing, finding no significant differences in gene expression or subcluster composition.