Author

Matt Davis

Thomas Jefferson UniversityORCID 0009-0002-0889-2181Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1 Assay:multiome· 1

Frequent Co-Authors

Ashleigh SmirnoviD· 1 shared Bede PortziD· 1 shared Ben E. BlackiD· 1 shared Bo Lim LeeiD· 1 shared Brigid K. JenseniD· 1 shared Busra OzguneyiD· 1 shared Christopher J. DonnellyiD· 1 shared Cristian A BergmanniD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Ashleigh SmirnovORCID

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1 paper

Recent·Most cited

Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration

Katie E. Copley, Jocelyn C. Mauna, Helen L. Danielson, Qizan Chen, Busra Ozguney, Marilyn Ngo, Longxin Xie, Ashleigh Smirnov, Matt Davis, Leland C. Mayne, Miriam Linsenmeier, Jack D. Rubien, Cristian A Bergmann, Bede Portz, Bo Lim Lee, , James Shorter

Short UG-rich RNAs bind and stabilize TDP-43 RNA-recognition motifs to allosterically destabilize its prion-like domain helical region, preventing aggregation and mitigating neurodegeneration in cells and mice.

Science · May 7, 2026Peer-reviewedBiochemistry✦ In-depth digest