A lactate-dependent shift of glycolysis mediates synaptic and cognitive processes
Ignacio Fernández‐Moncada, Gianluca Lavanco, Unai B. Fundazuri, Nasrin Bollmohr, Sarah Mountadem, Pauline Hachaguer, Francisca Julio‐Kalajzić, Doriane Gisquet, Tommaso Dalla Tor, Román Serrat, Luigi Bellocchio, Astrid Cannich, Bérénice Fortunato-Marsol, Yusuke Nasu, Robert E. Campbell, , Giovanni Marsicano
The paper shows lactate-dependent glycolysis shifts produce D-serine, linking astrocyte metabolism to synaptic and cognitive functions through CB1 receptor activation.
bioRxiv · Mar 15, 2023 · PreprintNeuroscience