Author

Katie E. Mulholland

Babraham InstituteORCID 0009-0002-5060-7401Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:protein structure· 1

Frequent Co-Authors

Hayley J. SharpeiD· 2 shared Tiffany LaiiD· 2 shared Claire E. EyersiD· 1 shared Daria EzeriņaiD· 1 shared Dominic P. ByrneiD· 1 shared Iain M. HayiD· 1 shared J. MessensiD· 1 shared Janet Elwyn DeaneiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMolecular Biology

Hayley J. SharpeORCID

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2 papers

Recent·Most cited

Molecular BiologyScience SignalingPeer-reviewedJan 20, 2026

Pervanadate-induced oxidation relieves autoinhibition of SRC protein tyrosine kinase

Katie E. Mulholland, Maxime Bourguet, Nuo Cheng…·Hayley J. Sharpe

This paper shows that pervanadate induces oxidation, which activates SRC kinases by disrupting autoinhibition and altering SH2 domain phosphopeptide binding, revealing a redox-dependent mechanism for SRC activation.

8 citationstop 1%

experimental assay

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Molecular BiologyeLifePeer-reviewedOct 20, 2022

Molecular mechanism of Afadin substrate recruitment to the receptor phosphatase PTPRK via its pseudophosphatase domain

Iain M. Hay, Katie E. Mulholland, Tiffany Lai…·Janet Elwyn Deane

The paper identifies how Afadin is recruited to PTPRK via its pseudophosphatase domain, revealing that substrate specificity is determined by interactions outside the active site.

3 citations

protein structureexperimental assay

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