Hayley J. Sharpe

This study identifies PTPRF as a stress-responsive cytoskeletal checkpoint that coordinates metabolic adaptation in hepatocytes and β cells by linking metabolic stress to actin reorganization.

The paper develops FlyPer, a Drosophila H2O2 biosensor toolkit, to measure subcellular H2O2 dynamics in vivo, revealing tissue-specific redox patterns during development and stress.

This study shows that loss of PTPRK in hepatocytes reduces steatosis and tumour development in obesity-induced hepatocellular carcinoma.

This paper shows that pervanadate induces oxidation, which activates SRC kinases by disrupting autoinhibition and altering SH2 domain phosphopeptide binding, revealing a redox-dependent mechanism for SRC activation.

This study identifies NHSL1's role in promoting fast endophilin-mediated endocytosis by interacting with EndoA2 and Ena/VASP proteins, enhancing actin polymerization at FEME sites.

The paper identifies how Afadin is recruited to PTPRK via its pseudophosphatase domain, revealing that substrate specificity is determined by interactions outside the active site.