Joris Messens

PTPRF is a stress responsive cytoskeletal checkpoint that coordinates metabolic adaptation in hepatocytes and β cells

This study identifies PTPRF as a stress-responsive cytoskeletal checkpoint that coordinates metabolic adaptation in hepatocytes and β cells by linking metabolic stress to actin reorganization.

Disease-linked mutations in hnRNPA2B1 accelerate condensate maturation and promote amyloid aggregation

This study shows disease-linked mutations in hnRNPA2B1 accelerate condensate maturation and promote amyloid aggregation by altering phase separation and fibril formation.

Challenges in reconstituting the peroxiredoxin 2:STAT3 transient redox-relay complex in vitro

This study attempts to reconstitute the transient Prdx2:STAT3 redox-relay complex in vitro but finds it challenging due to its redox-dependent nature and susceptibility to hyperoxidation.

Pervanadate-induced oxidation relieves autoinhibition of SRC protein tyrosine kinase

This paper shows that pervanadate induces oxidation, which activates SRC kinases by disrupting autoinhibition and altering SH2 domain phosphopeptide binding, revealing a redox-dependent mechanism for SRC activation.

Heterooligomerization drives structural plasticity of eukaryotic peroxiredoxins

The paper shows that eukaryotic Prx1/AhpC-type peroxiredoxins form heterooligomers, which modulate their structure and stability, challenging the previous belief in homooligomerization.

The nuclear sulfenome of Arabidopsis: spotlight on histone acetyltransferase GCN5 regulation through functional thiols

This study identifies 225 redox-active nuclear proteins in Arabidopsis, including GCN5, modified by sulfenylation under oxidative stress, revealing their functional impact on protein interactions.

Thermal Proteome Profiling reveals rapid proteomic responses to redox changes in specific cellular compartments

This study uses Thermal Proteome Profiling to identify proteomic responses to localized H2O2 production in different cellular compartments.

Functionally annotating cysteine disulfides and metal binding sites in the plant kingdom using AlphaFold2 predicted structures

The paper uses AlphaFold2 predicted structures to analyze cysteine disulfides and metal binding sites in plant proteomes, finding high agreement with experimental structures and evolutionary trends in metal binding.