Tiffany Lai

This study identifies PTPRF as a stress-responsive cytoskeletal checkpoint that coordinates metabolic adaptation in hepatocytes and β cells by linking metabolic stress to actin reorganization.

Shape2Fate tracks and classifies exocytic and endocytic carriers in live cells using morphology-aware deep learning, revealing pathway-specific exo-endocytic coordination rules.

This study shows that loss of PTPRK in hepatocytes reduces steatosis and tumour development in obesity-induced hepatocellular carcinoma.

This paper shows that pervanadate induces oxidation, which activates SRC kinases by disrupting autoinhibition and altering SH2 domain phosphopeptide binding, revealing a redox-dependent mechanism for SRC activation.

The paper identifies how Afadin is recruited to PTPRK via its pseudophosphatase domain, revealing that substrate specificity is determined by interactions outside the active site.