The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-alpha-inhibitor regulate crosslinking of the hyaluronan matrix
Anokhi Shah, Xiaoli Zhang, M. Snee, Michael P. Lockhart‐Cairns, Colin Levy, Thomas A. Jowitt, Holly L. Birchenough, Louisa Dean, Richard F. Collins, Rebecca J. Dodd, Abigail R. E. Roberts, Jan J. Enghild, Alberto Mantovani, Juan Fontana, Clair Baldock, , Anthony J. Day
This paper investigates how PTX3's quaternary structure enables HA crosslinking via interactions with HC1, revealing pH-dependent binding and structural flexibility.
Matrix Biology · Jan 13, 2025Peer-reviewedBiochemistry