Author

Olli Vaurio

University of Eastern FinlandORCID 0009-0002-7660-417XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:differential expression· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

Ilkka Ojansuu· 4 shared Jari KoıstınahoiD· 4 shared Jari TiihoneniD· 4 shared Marja KoskuviiD· 4 shared Šárka LehtoneniD· 4 shared Markku LähteenvuoiD· 3 shared Jaana SuvisaariiD· 2 shared Jouko K LönnqvistiD· 2 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

Ilkka Ojansuu

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4 papers

Recent·Most cited

A schizophrenia-associated radial glia cell state perturbs early human brain development

Susmita Malwade, Samudyata Samudyata, Jessica Gracias Lekander, Angelika Langeder, Katharina Weinberger, Marja Koskuvi, Ana Osório Oliveira, Šárka Lehtonen, Luis Enrique Arroyo‐García, Aiden Peter Corvin, Sarah E. Bergen, Ilkka Ojansuu, Olli Vaurio, Jari Koıstınaho, Jari Tiihonen, Carl M. Sellgren

This study identifies a schizophrenia-associated radial glia cell state that disrupts early human brain development through single-cell transcriptomic and epigenomic analyses of organoids.

bioRxiv · Oct 24, 2025 · PreprintNeuroscience

Astrocytes regulate neuronal network burst frequency through NMDA receptors species- anddonor-specifically

Noora Räsänen, Jari Tiihonen, Marja Koskuvi, Šárka Lehtonen, Nelli Jalkanen, Nelli Karmila, Isabelle Weert, Olli Vaurio, Ilkka Ojansuu, Markku Lähteenvuo, Olli P. H. Pietiläinen, Jari Koıstınaho

The paper shows human astrocytes influence neuronal network burst frequency via NMDA receptors, with differences between human and rat astrocytes and effects in schizophrenia-related cells.

bioRxiv · Dec 9, 2023 · PreprintNeuroscience

Molecular signaling pathways underlying schizophrenia

Jari Tiihonen, Marja Koskuvi, Markku Lähteenvuo, Kalevi Trontti, Ilkka Ojansuu, Olli Vaurio, Tyrone D. Cannon, Jouko K Lönnqvist, Sebastian Therman, Jaana Suvisaari, Lesley Cheng, Antti J. Tanskanen, Heidi T. Taipale, Šárka Lehtonen, Jari Koıstınaho

The paper identifies molecular pathways and potential treatments for schizophrenia using stem cell-derived neurons and pharmacological associations.

Schizophrenia Research · May 15, 2021Peer-reviewedNeuroscience

Patient iPSC-astrocytes show transcriptional and functional dysregulation in schizophrenia

Marja Koskuvi, Šárka Lehtonen, Kalevi Trontti, Meike Hedwig Keuters, Ying Chieh Wu, Hennariikka Koivisto, Anastasia Ludwig, L. M. Plotnikova, Pekka L. J. Virtanen, Noora Räsänen, Satu Kaipainen, Ida Hyötyläinen, Hiramani Dhungana, Raisa Giniatullina, Ilkka Ojansuu, , Jari Koıstınaho

The paper shows that astrocytes from schizophrenia patients exhibit transcriptional and functional changes, including inflammation and synaptic pathway alterations, which are partially reversible with clozapine treatment.

bioRxiv · Oct 23, 2020 · PreprintNeuroscience