Tyrone D. Cannon

Unique functional neuroimaging signatures of genetic versus clinical high risk for psychosis

The paper compares functional brain measures between 22qDel and CHR cohorts, finding distinct patterns of connectivity and variability disruptions.

Household income does not affect the pleiotropy of schizophrenia genetic liability with mental and physical health outcomes

The paper investigates the genetic correlation between schizophrenia and household income, finding no significant effect of socioeconomic status on schizophrenia's pleiotropy with health outcomes.

Linking Choroid Plexus Enlargement with Plasma Analyte and Structural Phenotypes in Clinical High Risk for Psychosis: A Multisite Neuroimaging Study

This study finds that individuals at clinical high risk for psychosis have larger choroid plexus volumes, associated with neuroanatomical changes and plasma analyte markers.

Identifying Nootropic Drug Targets via Large-Scale Cognitive GWAS and Transcriptomics

This paper identifies potential nootropic drug targets by integrating large-scale cognitive GWAS and transcriptomic data to find credible druggable genes.

Molecular signaling pathways underlying schizophrenia

The paper identifies molecular pathways and potential treatments for schizophrenia using stem cell-derived neurons and pharmacological associations.

Genetic and clinical analyses of psychosis spectrum symptoms in a large multi-ethnic youth cohort reveal significant link with ADHD.

The paper investigates genetic risk for psychosis spectrum symptoms in youth, finding a significant link with ADHD polygenic scores and age-specific effects.

Identifying Neural Signatures Mediating Behavioral Symptoms and Psychosis Onset: High-Dimensional Whole Brain Functional Mediation Analysis

The paper identifies neural mediators and brain regions associated with behavioral symptoms and psychosis onset using high-dimensional functional mediation analysis in clinical high-risk individuals.

Patient iPSC-astrocytes show transcriptional and functional dysregulation in schizophrenia

The paper shows that astrocytes from schizophrenia patients exhibit transcriptional and functional changes, including inflammation and synaptic pathway alterations, which are partially reversible with clozapine treatment.

Reliability of Mismatch Negativity Event-Related Potentials in a Multisite, Traveling Subjects Study

The paper evaluates MMN reliability across multiple EEG sites using different preprocessing methods, finding that mastoid referencing improves reliability.

Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

The paper uses pleiotropic meta-analysis to identify genetic loci associated with cognition, education, and schizophrenia, revealing distinct biological mechanisms for concordant and discordant genetic correlations.

Variants in regulatory elements of PDE4D associate with Major Mental Illness in the Finnish population

The paper identifies rs165940 as a functional variant in the PDE4D gene associated with major mental illness in the Finnish population, particularly psychosis and cognitive domains.

Progressive reconfiguration of resting-state brain networks as psychosis develops: Preliminary results from the North American Prodrome Longitudinal Study (NAPLS) consortium

The paper examines longitudinal changes in resting-state brain networks in individuals at clinical high risk for psychosis and finds reduced network efficiency and increased diversity in those who later develop psychosis.

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

This study identifies 206 new genomic loci and 1,041 genes associated with intelligence using a large GWAS meta-analysis of 279,930 individuals.

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

This study identifies 99 genetic loci associated with general cognitive function using data from 280,360 individuals, finding genes linked to brain structure and neurodegenerative disorders.

The NDE1 genomic locus can affect treatment of psychiatric illness through gene expression changes related to MicroRNA-484

The paper investigates how genetic variation at the NDE1 locus affects gene expression and treatment response to psychiatric medications through interactions with microRNA-484 and CYP2C19.

Large-Scale cognitive GWAS Meta-analysis Reveals Tissue-Specific Neural Expression and Potential Nootopic Drug Targets

This study performs a large-scale GWAS of cognitive ability, identifies 70 genomic loci, and finds tissue-specific gene expression and potential drug targets.

Toward leveraging big data in human functional connectomics: Generalization of brain graphs across scanners, sessions, and paradigms

The paper assesses the reliability of functional connectomic measures across different scanners, sessions, and paradigms, finding fair to excellent reliability and demonstrating achievable statistical power in multisite studies.