Nicole Blakeley

Purinergic receptor activation rectifies autism-associated endothelial dysfunction

This study shows that purinergic receptor activation can correct endothelial dysfunction linked to autism in a mouse model by restoring bioenergetic function and cerebrovascular reactivity.

Metabolic, epigenetic and transcriptomic alterations in postnatal 16p11.2 deficient murine astrocytes

This study examines metabolic, epigenetic, and transcriptomic changes in astrocytes from a mouse model of 16p11.2 deletion ASD syndrome, revealing sex-specific molecular alterations.

Astroglial Hmgb1 regulates postnatal astrocyte morphogenesis and cerebrovascular maturation.

This study identifies Hmgb1 in astrocytes as critical for postnatal astrocyte morphogenesis and cerebrovascular maturation, affecting endothelial ultrastructure and neurovascular coupling in adult mice.