Astroglial Hmgb1 regulates postnatal astrocyte morphogenesis and cerebrovascular maturation.
Moises Freitas Andrade, Cesar Henrique Comin, Peter C. Van Dyken, Julie Ouellette, Joanna Raman‐Nair, Nicole Blakeley, Qing Yan Liu, Sonia Leclerc, Youlian Pan, Ziying Liu, Micaël Carrier, Karan Thakur, Alexandre Savard, Gareth M. Rurak, Marie‐Ève Tremblay, , Baptiste Lacoste
This study identifies Hmgb1 in astrocytes as critical for postnatal astrocyte morphogenesis and cerebrovascular maturation, affecting endothelial ultrastructure and neurovascular coupling in adult mice.
bioRxiv · Apr 29, 2023 · PreprintDevelopmental Biology