This study shows that purinergic receptor activation can correct endothelial dysfunction linked to autism in a mouse model by restoring bioenergetic function and cerebrovascular reactivity.

Neuron · Sep 1, 2026Peer-reviewedCell Biology

Zebrafish glial-vascular interactions progressively expand over the course of brain development

L. Gall, Courtney M Stains, Moises Freitas Andrade, Bill Jia, Nishi H. Patel, Sean G. Megason, Baptiste Lacoste, Natasha M. O’Brown

This study examines glial-vascular interactions in zebrafish brains across development, showing increasing glial coverage over time, with lower adult coverage compared to mammals.

iScience · Dec 9, 2024Peer-reviewedDevelopmental Biology

Astroglial Hmgb1 regulates postnatal astrocyte morphogenesis and cerebrovascular maturation.

Moises Freitas Andrade, Cesar Henrique Comin, Peter C. Van Dyken, Julie Ouellette, Joanna Raman‐Nair, Nicole Blakeley, Qing Yan Liu, Sonia Leclerc, Youlian Pan, Ziying Liu, Micaël Carrier, Karan Thakur, Alexandre Savard, Gareth M. Rurak, Marie‐Ève Tremblay, , Baptiste Lacoste

This study identifies Hmgb1 in astrocytes as critical for postnatal astrocyte morphogenesis and cerebrovascular maturation, affecting endothelial ultrastructure and neurovascular coupling in adult mice.

bioRxiv · Apr 29, 2023 · PreprintDevelopmental Biology

Translatomic database of cortical astroglia across male and female mouse development reveals two distinct developmental phenotypes

Gareth M. Rurak, Stephanie Simard, Moises Freitas Andrade, Baptiste Lacoste, François Charih, Amanda Van Geel, John D. H. Stead, Barbara Christine Woodside, James R. Green, Gianfilippo Coppola, Natalina Salmaso

The paper identifies two distinct astroglial phenotypes across mouse cortical development and reveals significant sex differences in developmental gene expression patterns.

Cell Reports · Feb 1, 2022Peer-reviewedNeuroscience