Rongrong Du

This study designs synthetic reaction-diffusion circuits in mammalian cells to generate spatial patterns with controllable spatial scales.

The paper introduces DIMMERs, miRNA-based circuits that enable precise, tunable control of transgene expression across cell types, improving gene therapy and research applications.

A synthetic miRNA-based incoherent feed-forward loop circuit embedded in a gene delivery vector overcomes the challenge of overexpression toxicity in a mouse model of Rett syndrome gene therapy.