David Peles

This study shows that Baicalin treatment reduces behavioral and physiological deficits in Gtf2i-duplication mice and enhances synaptic activity in 7Dup patient-derived neurons.

This study identifies 31 commonly dysregulated genes across seven neurological disorders, enriched in brain ECM pathways, suggesting distinct ECM changes in disease states.

The paper compares behavioral and physiological effects of Gtf2i duplication and deletion in mouse models of 7q11.23 duplication and Williams-Beuren Syndromes, identifying dosage-dependent differences in social behavior and thermoregulation.

DeePosit detects and classifies urine and fecal deposits in mice from thermal videos, showing distinct dynamics in test, strain, and sex contexts.

The paper compares genetic and cellular differences between autism and schizophrenia using GWAS and iPSC-derived neurons, finding shared SNPs and similar synaptic deficits.

This study compares neuronal phenotypes from monozygotic twins discordant for schizophrenia, finding differences in synaptic activity and neuronal maturation between affected and unaffected siblings.

The paper investigates how LFP rhythmicity in the social brain of mice reflects social context during social discrimination tasks.

The paper shows that cortical neurons from ASD-associated mutations exhibit early maturation and hyperexcitability compared to controls.

This paper reviews genomic studies and iPSC-based models of schizophrenia to summarize current progress in understanding its genetic basis and cellular mechanisms.