Shlomo Wagner

Sex differences in neural activity across amygdalo-striatal network during social behaviour

This study identifies sex differences in neural activity across the amygdalo-striatal network during social behaviour in mice, with distinct anticipatory states and context-dependent dynamics in the basolateral amygdala.

Dynamic corticostriatal neural coordination governs competition between social and metabolic drives in rats

This study shows that social isolation shifts preference toward social engagement in rats, accompanied by changes in corticostriatal neural coordination and oxytocin signaling.

Extracellular Vesicles from Stem cells Rescue Cellular Phenotypes and Behavioral Deficits in SHANK3-Associated ASD Neuronal and Mouse Models

This study shows that EVs from stem cells can rescue cellular and behavioral deficits in Shank3-deficient models of ASD.

Oxytocin facilitates social behavior of female rats via selective modulation of interneurons in the medial prefrontal cortex

This study identifies a circuit in the medial prefrontal cortex where oxytocin modulates interneurons to promote social behavior in female rats, even under physiological stress.

Baicalin ameliorates behavioral and physiological deficits in Gtf2i-duplication mice and modulates synaptic activity in 7q11.23 Duplication Syndrome patient-derived neurons

This study shows that Baicalin treatment reduces behavioral and physiological deficits in Gtf2i-duplication mice and enhances synaptic activity in 7Dup patient-derived neurons.

Inhibition governs preference encoding in medial prefrontal cortex pyramidal neurons during a binary social choice in mice

The paper shows that inhibition in mPFC pyramidal neurons during social choice tasks encodes stimulus preference, guiding decision-making in mice.

Contrasting behavioral and physiological effects of Gtf2i duplication and deletion in mouse models of the 7q11.23 Duplication and Williams-Beuren Syndromes

The paper compares behavioral and physiological effects of Gtf2i duplication and deletion in mouse models of 7q11.23 duplication and Williams-Beuren Syndromes, identifying dosage-dependent differences in social behavior and thermoregulation.

DeePosit: an AI-based tool for detecting mouse urine and fecal depositions from thermal video clips of behavioral experiments

DeePosit detects and classifies urine and fecal deposits in mice from thermal videos, showing distinct dynamics in test, strain, and sex contexts.

Altered neural activity in the mesoaccumbens pathway underlies impaired social reward processing in Shank3-deficient rats

This study shows that Shank3-deficient rats have altered neural activity in the mesoaccumbens pathway, leading to impaired social reward processing, and that manipulating VTA activity can normalize behavior.

Distinct prelimbic cortex neuronal responses to emotional states of others drive emotion recognition in adult male mice

The paper shows that distinct neuronal responses in the prelimbic cortex of mice to emotional states of others drive emotion recognition, with disruptions linked to ASD-like social deficits.

Synchronized LFP rhythmicity in the social brain reflects the context of social encounters

The paper investigates how LFP rhythmicity in the social brain of mice reflects social context during social discrimination tasks.

Impaired emotion recognition in Cntnap2-deficient mice is associated with hyper-synchronous prefrontal cortex neuronal activity

This study shows that Cntnap2-deficient mice have impaired emotion recognition linked to hyper-synchronous prefrontal cortex activity during social tasks.

Cell types in the mouse amygdala and their transcriptional response to fear conditioning

The paper identifies cell types in the mouse amygdala and their transcriptional response to fear conditioning using single-cell RNA-seq and spatial transcriptomics.

Neural activity and theta rhythmicity in the anterior hypothalamic nucleus are involved in regulating social investigation

This study investigates the role of anterior hypothalamic nucleus (AHN) neurons in social interactions, finding that theta rhythmicity and spiking activity in AHN are context-dependent and influence approach and avoidance behaviors.

Oxytocin activity in the Paraventricular and Supramammillary Nuclei of the Hypothalamus is Essential for Social Recognition Memory in Rats

This study identifies the supramammillary nucleus as a target of PVH oxytocin neurons and shows its necessity for social recognition memory in rats.

Precision medicine for the rescue of specific impairments in social behavior associated with the A350V Iqsec2 mutation

This study shows that enhancing AMPAR-mediated synaptic transmission with PF-4778574 rescues specific social behavior deficits in A350V Iqsec2 mice.