John C. Christianson

TMEM33 deletion potentiates anti-tumor CD8+ T cell immunity

This study shows TMEM33 limits progenitor-exhausted CD8+ T cells, enhances anti-tumor responses, and correlates with improved survival in melanoma patients.

The KDM6 histone demethylase inhibitor GSK-J4 induces metal and stress responses in multiple myeloma cells

This study shows GSK-J4, a KDM6 inhibitor, induces metal and stress responses in multiple myeloma cells by increasing intracellular Zn2+ and activating metallothionein gene expression.

A critical role for the ER Membrane Complex (EMC) in lipid droplet homeostasis

This study shows that the EMC3 subunit is critical for lipid droplet homeostasis in mice and Drosophila, with loss of EMC3 causing triglyceride storage defects and reduced FITM2 levels.

ATF4-Mediated Metabolic Stress Response as a Therapeutic Vulnerability in Chordoma

This study identifies ATF4-mediated metabolic stress response as a therapeutic target in chordoma, showing that EPRS inhibitors reduce cell viability and inhibit tumor growth in vivo.