Author

Lucia Cottone

University College LondonORCID 0000-0002-9397-4925Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Lorena Ligammari· 3 shared Adrienne Margaret FlanaganiD· 2 shared Adam Cribbs· 1 shared Adam P. CribbsiD· 1 shared Adrienne M Flanagan· 1 shared Anthony Tumber· 1 shared Calum ConnollyiD· 1 shared Catrine Johannson· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersCancer Biology

Lorena Ligammari

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Oncolytic virus-antibody combinations enhance immune-mediated killing of osteosarcoma

Tyler Barr, Lucia Cottone, Katherine Stanton, Victoria A. Jennings, Shaoli Das, Richard T. Baugh, Jonathan Daniel Stevenson, Hardev Pandha, Guy R. Simpson, Justas Stanislovas, Heather Elizabeth Owston, Dennis McGonagle, Peter Vasilios Giannoudis, Natasha J. Caplen, Sandra J. Strauss, , Graham P. Cook

This study shows that combining oncolytic viruses with antibodies enhances immune-mediated killing of osteosarcoma by overcoming immunosuppression.

bioRxiv · Sep 16, 2026 · PreprintCancer Biology

ATF4-Mediated Metabolic Stress Response as a Therapeutic Vulnerability in Chordoma

Lucia Cottone, James E. Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Giorgia Gaeta, John C. Christianson, Adrienne Margaret Flanagan, Udo C. T. Oppermann, Adam P. Cribbs

This study identifies ATF4-mediated metabolic stress response as a therapeutic target in chordoma, showing that EPRS inhibitors reduce cell viability and inhibit tumor growth in vivo.

bioRxiv · Feb 27, 2025 · PreprintCancer Biology

An efficient and adaptable workflow for editing disease-relevant single nucleotide variants using CRISPR/Cas9

Inga Usher, Lorena Ligammari, Sara Ahrabi, Emily Hepburn, Calum Connolly, Gareth L. Bond, Adrienne Margaret Flanagan, Lucia Cottone

The paper describes a workflow for efficient single nucleotide variant editing using CRISPR/Cas9, showing how experimental conditions affect editing efficiency and introducing methods for screening and quality control.

bioRxiv · Nov 12, 2021 · PreprintMolecular Biology

Epigenetic inactivation of oncogenic brachyury (TBXT) by H3K27 histone demethylase controls chordoma cell survival

Lucia Cottone, Edward S Hookway, Adam Cribbs, Graham Wells, Patrick Lombard, Lorena Ligammari, Anthony Tumber, Roberto Tirabosco, Fernanda Amary, Tamas Szommer, Catrine Johannson, Paul E Brennan, Nischalan Pillay, Udo Oppermann, Adrienne M Flanagan

This study shows that inhibiting H3K27 demethylases reduces TBXT expression and kills chordoma cells by altering epigenetic marks and gene expression.

bioRxiv · Oct 1, 2018 · PreprintCancer Biology