Yifei Weng

The paper profiles single-nucleus RNA sequencing data from male and hermaphrodite C. elegans neurons to identify sex-specific and sex-shared transcriptional regulators of behavior.

Single-nucleus RNA sequencing of adult C. elegans neurons identifies transcriptional changes in daf-2 mutants related to chemosensation, learning, and memory.

This study investigates the IIS/FOXO pathway's role in cognitive aging using C. elegans, finding that daf-2 mutants exhibit distinct transcriptomic changes that enhance neuronal resilience.

This study identifies sex-dimorphic neuronal aging features in C. elegans males and hermaphrodites, revealing differential gene expression and X-chromosomal dysregulation associated with cognitive decline.

Activating the Gαq pathway in aged worms and mice improves memory and cognitive function, demonstrating conservation across species.