Karishma J. B. Pratt

COUNTERING AGE-ASSOCIATED ALTERATIONS IN OLIGODENDROCYTE-DERIVED EXTRACELLULAR MATRIX REJUVENATES COGNITION

The paper shows that reversing age-related changes in oligodendrocyte-derived extracellular matrix improves cognition in aged mice.

Spatial Coding Dysfunction and Network Instability in the Aging Medial Entorhinal Cortex

This study examines spatial coding dysfunction and network instability in aged medial entorhinal cortex using in vivo electrophysiology and gene expression analysis in mice.

Endogenous neuronal DNA double-strand breaks are not sufficient to drive brain aging and neurodegeneration

This study shows that neuronal DNA double-strand breaks, even when accumulated due to loss of C-NHEJ, do not drive brain aging or neurodegeneration in mice.

Neuronal Activation of the Gαq Protein EGL-30/GNAQ Late in Life Rejuvenates Cognition Across Species

Activating the Gαq pathway in aged worms and mice improves memory and cognitive function, demonstrating conservation across species.

Unique Transcription Factor Functions Regulate Epigenetic and Transcriptional Dynamics During Cardiac Reprogramming

This study investigates how Gata4, Mef2c, and Tbx5 drive cardiac reprogramming by analyzing transcriptomic and epigenomic changes in fibroblasts.