Author

Kyle Polen

University of PennsylvaniaORCID 0009-0003-7775-111XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Robert J. LeeiD· 3 shared Ryan M. CareyiD· 3 shared Gavin TurneriD· 2 shared Lily HuangiD· 2 shared Sarah M. SywanycziD· 2 shared Zoey A. MilleriD· 2 shared Brianna L. HilliD· 1 shared James N. PalmeriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersCancer Biology

Robert J. LeeORCID

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3 papers

Recent·Most cited

PhysiologybioRxivPreprintOct 25, 2026

Targeting cyclic-AMP/phosphodiesterase signaling to quiet nasal tuft cell calcium responses

Kyle Polen, Li Eon Kuek, Zhongming Ma…·Robert J. Lee

This study investigates the role of cyclic-AMP/phosphodiesterase signaling in modulating nasal tuft cell calcium responses and IL-25 release using mouse and human models.

DOI 10.64898/2026.10.21.760783

mousehuman

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Cancer BiologybioRxivPreprintJul 27, 2026

TAS2R10 Suppresses ABCG2 Transporter-Associated Chemoresistance and Enhances Cisplatin Sensitivity in Head and Neck Squamous Cell Carcinoma

Lily Huang, Sarah M. Sywanycz, Priyanka Sahu…·Ryan M. Carey

This study shows caffeine enhances cisplatin sensitivity in HNSCC by increasing TAS2R10 expression and reducing ABCG2 expression.

DOI 10.64898/2026.07.26.740768

humanbulk RNA-seq

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Cancer BiologyMolecular Cancer TherapeuticsPeer-reviewedNov 7, 2025

T2R5 agonist phendione decreases cell viability and induces apoptosis in head and neck squamous cell carcinoma

Sarah M. Sywanycz, Brianna L. Hill, Zoey A. Miller…·Ryan M. Carey

Phendione, a T2R5 agonist, reduces cell viability and induces apoptosis in HNSCC cells and tumor samples, with T2R5 expression linked to better survival in HNSCC.

1 citation

humanbulk RNA-seq

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