Ryan M. Carey

Targeting cyclic-AMP/phosphodiesterase signaling to quiet nasal tuft cell calcium responses

This study investigates the role of cyclic-AMP/phosphodiesterase signaling in modulating nasal tuft cell calcium responses and IL-25 release using mouse and human models.

TAS2R10 Suppresses ABCG2 Transporter-Associated Chemoresistance and Enhances Cisplatin Sensitivity in Head and Neck Squamous Cell Carcinoma

This study shows caffeine enhances cisplatin sensitivity in HNSCC by increasing TAS2R10 expression and reducing ABCG2 expression.

Pseudomonas aeruginosa metabolite 3-oxo-C12HSL induces apoptosis through T2R14 and the mitochondrial calcium uniporter

This study shows that 3-oxo-C12HSL from Pseudomonas aeruginosa induces apoptosis in HNSCC cells via T2R14 and mitochondrial calcium uniporter.

Therapeutic scheduling of WEE1 inhibition preserves T cell function and promotes immune control of HPV+ tumors

This study shows that intermittent WEE1 inhibition preserves T cell function and enhances immune control of HPV+ tumors through non-cell-autonomous immune activation mechanisms.

Effects of Pseudomonas aeruginosa pyocyanin and 1-hydroxyphenazine on intracellular calcium, mitochondrial function, and viability in human nasal epithelial cells

This study investigates the effects of pyocyanin and 1-hydroxyphenazine on calcium signaling, mitochondrial function, and cell viability in nasal epithelial cells and cancer cell lines.

T2R5 agonist phendione decreases cell viability and induces apoptosis in head and neck squamous cell carcinoma

Phendione, a T2R5 agonist, reduces cell viability and induces apoptosis in HNSCC cells and tumor samples, with T2R5 expression linked to better survival in HNSCC.

Quercetin as a Bitter Taste Receptor Agonist with Anticancer Effects in Head and Neck Cancer Cells

This study shows quercetin activates T2R14 in HNSCC cells, causing calcium responses, reduced viability, and mitochondrial depolarization.

Bitter Taste Receptor Agonists Induce Apoptosis in Papillary Thyroid Cancer

This study shows bitter taste receptor agonists induce apoptosis in papillary thyroid cancer cells and higher TAS2R14 expression correlates with better patient survival.