Author

Shean Fu Phen

New York UniversityORCID 0009-0003-8413-710XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:whole-genome sequencing· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Assay:DNA methylation· 1

Frequent Co-Authors

David M. TruongiD· 2 shared Susanna JaramilloiD· 2 shared Tomoki YanagiiD· 2 shared Bryan Yi· 1 shared Deniz Ece AydiniD· 1 shared Jonah AyalaiD· 1 shared LESLIE ANN MITCHELLiD· 1 shared Megan S. HoganiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersSynthetic Biology

David M. TruongORCID

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2 papers

Recent·Most cited

REWRITE Enables Locus-Scale Engineering of Synthetic HLA Haplotypes in Human Pluripotent Stem Cells

Serena Generoso, Sarah Levovitz, Susanna Jaramillo, Minjoo Kim, Sumanth Dara, Shean Fu Phen, Bryan Yi, Tomoki Yanagi, Thomas L. DesMarais, Neta Agmon, Megan S. Hogan, LESLIE ANN MITCHELL, David M. Truong

REWRITE enables scar-minimized rewriting of native human loci exceeding 100 kb in hPSCs, demonstrated through synthetic refactoring of the class-I HLA region.

bioRxiv · Sep 16, 2025 · PreprintSynthetic Biology

Termination sequence between an inducible promoter and ubiquitous chromatin opening element (UCOE) reduces gene expression leakage and silencing

Tomoki Yanagi, Shean Fu Phen, Jonah Ayala, Deniz Ece Aydin, Susanna Jaramillo, David M. Truong

The paper investigates how spacer sequences between a promoter and A2UCOE affect gene expression leakage and silencing in iPSCs, finding that an AT-rich poly-A terminator reduces leakage and enhances anti-silencing.

Journal of Biological Engineering · Apr 9, 2025Peer-reviewedSynthetic Biology