Cancer BiologybioRxivPreprint
Deoxyuridine-rich cytoplasmic DNA antagonizes STING-dependent innate immune responses and sensitizes resistant tumors to anti-PD-L1 therapy
Pinakin Pandya, Frank P. Vendetti, Joseph El-Ghoubaira…·Christopher J. Bakkenist
The paper shows that dU-rich cytoplasmic DNA inhibits STING-dependent immune responses and enhances anti-PD-L1 therapy efficacy in tumors.
2 citations