Gene syntax defines supercoiling-mediated transcriptional feedback
Christopher P. Johnstone, Kasey S. Love, Sneha R Kabaria, Ross D. Jones, Albert Blanch-Asensio, Deon S. Ploessl, Emma L. Peterman, Rachel Lee, Jiyoung Yun, Conrad G. Oakes, Christine L. Mummery, Richard P. Davis, Brandon J. DeKosky, Peter W. Zandstra, Kate E. Galloway
The paper shows that gene syntax influences supercoiling-mediated transcriptional feedback, affecting adjacent gene expression in human cells.
Science · Apr 30, 2026Peer-reviewedSynthetic Biology