Author

Mengyao Lu

Purdue University West Lafayette

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Alicia N. RizzoiD· 1 shared Alisha DhimaniD· 1 shared Amy Zhao· 1 shared Anchen QiuiD· 1 shared Brittany L. Allen-PeterseniD· 1 shared Brittany N. HeiliD· 1 shared Charles S Dela Cruz· 1 shared Chittaranjan DasiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperImmunology

Alicia N. RizzoORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

A Time-Resolved Single-Cell Atlas Reveals Infection-Status, Age-, and Sex-Dependent Immune Responses Drive Viral Disease Severity

Lujia Chen, Anchen Qiu, JooYoung Kim, Nebal Abu Hussein, Mengyao Lu, Karen Agaronyan, Kexin Sun, Yifan Yuan, Amy Zhao, Gagan Heda, Xinghua Lu, Georgios D. Kitsios, Alicia N. Rizzo, William Bain, Toru Nyunoya, , Lokesh Sharma

This study uses time-resolved single-cell RNA sequencing in mice to show age and sex influence immune responses and viral disease severity through altered gene expression and inflammation.

bioRxiv · Aug 11, 2026 · PreprintImmunology

Identification, optimization, and structural elucidation of chloroacetamide scaffold as covalent inhibitors for Ubiquitin C-terminal Hydrolase L3

Nagabhushana C. Beeralingappa, Mengyao Lu, Rishi S. Patel, Nipuni M. Pannala, Alisha Dhiman, Brittany N. Heil, Ryan D. Imhoff, Emily G. Smith, Mei B Bahler, Haley L Marsden, Brittany L. Allen-Petersen, Mike Wendt, Chittaranjan Das, Daniel Patrick Flaherty

This study identifies and optimizes a chloroacetamide scaffold as a covalent inhibitor for UCHL3, supported by structural and biochemical validation.

bioRxiv · May 29, 2026 · PreprintPharmacology & Toxicology