Membrane protein condensates polymerize actin and form filopodia
Shannon Bareesel, Thomas J. Böddeker, Willem Bintig, Domonkos Nagy-Herczeg, Max Ruwolt, Vasiliki Syropoulou, Cristina Kroon, Patricia Kreis, Susanne Wegmann, Michal Szczepek, Christian M. T. Spahn, Patrick Scheerer, George Leondaritis, Fan Liu, Roland L. Knorr, Britta Johanna Eickholt
This study identifies PLPPR3 condensates as actin sinks that locally boost monomer concentrations, promoting actin polymerization and filopodia formation in neurons.
bioRxiv · Oct 9, 2025 · PreprintCell Biology