Robert N. S. Sachdev

Coordinated orienting behavior emerges following unilateral optogenetic activation of Superior Colliculus GABAergic neurons

This study shows that activating GABAergic neurons in the superior colliculus of mice triggers a coordinated sequence of orienting movements involving multiple effectors.

Cortex-wide laminar dynamics diverge during learning

The paper investigates how cortical layers change during learning, finding that layer 5 and 2/3 show distinct activity patterns across different brain regions and times.

Cortex-wide representational drift of different layers

The paper examines representational drift across different cortical layers and finds distinct spatial and temporal patterns in Layer 2/3 and Layer 5.

Tuft dendrites in frontal motor cortex enable flexible learning

The paper investigates the role of apical tuft dendrites in the anterolateral motor cortex in flexible learning using a rule-switching paradigm.

Behavioural Context Shapes Sensory Responses in Vibrissal Motor Cortex

The paper shows that neurons in the vibrissal motor cortex (vM1) respond differently to sensory stimuli depending on the behavioral context, with context-specific recruitment of neuronal populations.

mTORC1-Dependent Signaling in Layer 5b Neurons Is Required for Memory Consolidation

This study shows that mTORC1-dependent translation in layer 5b neurons is essential for memory consolidation through activity-dependent plasticity.

Orofacial movements: Individuality and stereotypy when mice move a single whisker to touch

This study investigates how mice control individual whisker movements and facial coordination during a whisking-to-touch task, revealing stereotyped patterns and fine motor control.

Context-dependent reshaping of defensive responses to predators in head-fixed and freely moving mice

This study shows that mice do not uniformly express defensive behaviors when exposed to predators, instead showing context-dependent and variable responses.

Refined movement analysis in the Staircase test reveals differential motor deficits in mouse models of stroke

The paper uses machine learning to analyze movement in mouse stroke models, revealing distinct motor deficits based on lesion location.

Layer 1 of somatosensory cortex: An important site for input to a tiny cortical compartment

The paper investigates input sources to layer 1 of mouse somatosensory cortex using retrograde tracing and optogenetics, revealing local and long-range contributions and their interactions.

Predicting behavior from eye movement and whisking asymmetry

The paper shows that whisker asymmetry predicts turn direction in mice earlier than eye movement during navigation tasks.

The impact of phosphorylated Pten at threonine 366 on cortical connectivity and behaviour

This study investigates the role of Pten T366 phosphorylation in cortical connectivity and behavior, finding that its disruption leads to cognitive deficits and sensory impairments in mice.

Whisking asymmetry signals motor preparation and the behavioral state of mice

The paper shows that whisker asymmetry in mice signals their behavioral state and motor preparation during a visual task.